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Journal of Child Neurology
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Article

Cerebellum Can Be a Possible Generator of Progressive Myoclonus

Kyung Nam Koh, MD1, Byung Chan Lim, MD1, Hee Hwang, MD1, June Dong Park, MD, PhD1, Jong Hee Chae, MD, PhD1*, Ki Joong Kim, MD, PhD1, Young-Seung Hwang, MD, PhD1, Seung-Ki Kim, MD, PhD2, Kyu-Chang Wang, MD, PhD2, and Han Ku Moon, MD, PhD3

1 Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
2 Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea
3 Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea

* To whom correspondence should be addressed. E-mail: chaeped1{at}snu.ac.kr.


  Abstract
A 19-month-old girl presented with progressive myoclonic jerking of both proximal lower extremities. On her brain magnetic resonance imaging (MRI), the authors found an ill-defined mass involving cerebellar vermis and the right middle cerebellar peduncle. 11C-methionine positron emission tomography (PET) showed no abnormalities, but 18F-fluorodeoxyglucose (18F-FDG) PET revealed a well-defined hypermetabolic focus. Depth electrodes were inserted deep into the mass, which recorded focal slow waves associated with the clinical myoclonus. Following the removal of the tumor, the myoclonus was completely resolved with no neurological deficit. Here, the authors present a case showing progressive myoclonus associated with a cerebellar ganglioglioma with the electrophysiological data, which provides strong supportive evidence that the cerebellum can be a myoclonus generator.

First published on September 22, 2009
Journal of Child Neurology 2009, doi:10.1177/0883073809342273
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