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Journal of Child Neurology
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A Randomized, Double-Blind, Crossover Study of Phenobarbital and Mephobarbital

Richard S. K. Young, MD

Departments of Neurology and Pediatrics, Yale University School of Medicine, New Haven, CT

Pamela M. Alger, BS, RN

Department of Pediatrics, Pennsylvania State University

Laurence Bauer, MSW

Department of Family Medicine, Pennsylvania State University

Debra Lauderbaugh, RPh

Department of Pharmacy the Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA

Some pediatric neurologists maintain that mephobarbital (Mebaral) causes fewer behavioral side effects than phenobarbital. Because this hypothesis has not been previously tested, we conducted a prospective, double-blind, randomized, crossover study of these two anticonvulsants. Both drugs were equally effective in reducing the frequency of seizure, although serum phenobarbital levels were significantly higher when the patients were taking phenobarbital compared to mephobarbital. As measured by the Abbott Parent Questionnaire, there was no significant deterioration of behavior with either phenobarbital or mephobarbital, regardless of which drug was administered first. J Child Neurol 1986;1:361-363)

Journal of Child Neurology, Vol. 1, No. 4, 361-363 (1986)
DOI: 10.1177/088307388600100408
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 J Child NeurolHome page
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[Abstract] [PDF]