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Journal of Child Neurology
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Clobazam for Intractable Pediatric Epilepsy

Raj D. Sheth, MD

Department of Neurology and Pediatrics West Virginia University, Health Science Center, Morgantown, WV

Gabriel M. Ronen, MD

Department of Pediatrics McMaster University Medical Center, Hamilton, Ontario

Keith J. Goulden, MD

Department of Pediatrics The Glenrose Children Rehabilitation Hospital, Edmonton, Alberta

Sharon Penney, RN

Janeway Child Health Center St John's, Newfoundland, Canada

John B. Bodensteiner, MD

Department of Neurology and Pediatrics West Virginia University, Health Science Center, Morgantown, WV

We report our experience with add-on clobazam therapy over a 5-year period in 63 children with refractory epilepsy. The mean duration of epilepsy was 6.7 years. Children were followed for 15 to 64 months. Of 63 children, 57 were developmentally delayed, and 54 had a symptomatic/cryptogenic epilepsy. Forty-one percent became either seizure free or had a greater than 90% reduction in seizure frequency. Seizure frequency was reduced 50% to 90% in another 24%. The average daily dose of clobazam was 0.8 mg/kg. Thirty-five percent had the medication withdrawn for persistent or unacceptable side effects or the development of tolerance (seven patients). Side effects included severe aggressive outbursts, hyperactivity, insomnia, and depression with suicidal ideation. Clobazam is a useful add-on medication for 65% of children with epilepsy. Clinical utility may be limited by behavioral side effects in some patients. (J Child Neurol 1995;10:205-208).

Journal of Child Neurology, Vol. 10, No. 3, 205-208 (1995)
DOI: 10.1177/088307389501000306
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J. G.W. Theis, G. Koren, R. Daneman, A. L. Sherwin, E. Menzano, M. Cortez, and P. Hwang
Interactions of Clobazam With Conventional Antiepileptics in Children
J Child Neurol, April 1, 1997; 12(3): 208 - 213.
[Abstract] [PDF]