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Neurobehavioral and Neurologic Outcome in Long-Term Survivors of Posterior Fossa Brain Tumors: Role of Age and Perioperative Factors

Department of Neurology Children's Hospital, Department of Neurology Harvard Medical School

Deborah P. Waber, PhD

Division of Psychology Children's Hospital, Department of Psychiatry Harvard Medical School

Jane H. Bernstein, PhD

Division of Psychology Children's Hospital, Department of Psychiatry Harvard Medical School

Scott L. Pomeroy, MD, PhD

Department of Neurology Children's Hospital, Department of Neurology Harvard Medical School

Beverly LaVally, RN, MS

Department of Pediatric Oncology Dana Farber Cancer Institute, Boston, MA

Stephen E. Sallan, MD

Department of Pediatrics Harvard Medical School, Department of Pediatric Oncology Dana Farber Cancer Institute, Boston, MA

Nancy Tarbell, MD

Department of Radiation Oncology Children's Hospital, Joint Center for Radiation Therapy Harvard Medical School

We evaluated the neuropsychological and neurologic outcome of 15 long-term survivors of posterior fossa tumors who were treated between 1970 and 1984 with cranial irradiation (n = 15) and surgery (n = 14). The interval between diagnosis and evaluation ranged from 4 to 20 years (median = 10 years). Earlier age at diagnosis (< 6 years) was associated with an increased incidence of severe neurologic and neuropsychological sequelae. Hydrocephalus, obtundation, and tumor extension outside the vermis also were more prevalent in the younger group. Poor neurobehavioral outcomes in young children with posterior fossa tumors may be related to more aggressive tumor growth or complications of the initial therapy and not solely due to toxicity from craniospinal irradiation. (J Child Neurol 1995;10:209-212).

Journal of Child Neurology, Vol. 10, No. 3, 209-212 (1995)
DOI: 10.1177/088307389501000308


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