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Journal of Child Neurology
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Models of Delayed Recovery

Alan Leviton, MD

Children's Hospital, Harvard Medical School and Harvard School of Public Health, Boston, MA

David Bellinger, PhD

Children's Hospital, Harvard Medical School and Harvard School of Public Health, Boston, MA

Marcello Pagano, PhD

Children's Hospital, Harvard Medical School and Harvard School of Public Health, Boston, MA

Michael Rabinowitz, PhD

Children's Hospital, Harvard Medical School and Harvard School of Public Health, Boston, MA

After a biologic insult has impaired function of the developing central nervous system, recovery may not become apparent for years. Probability models adopted from the carcinogenesis, developmental neurobiology, learning decay, and stochastic process literatures are presented so that assumptions about apparent delays in the recovery process can be tested with data from longitudinal studies after a temporally circumscribed adverse event/exposure. This process of evaluating multiple models is exemplified with one data set. Nonlinear models of recovery are important because some children with early deficits first show improvement months to years later. (J Child Neurol 1995; 10: 385-39 1).

Journal of Child Neurology, Vol. 10, No. 5, 385-391 (1995)
DOI: 10.1177/088307389501000509
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