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Journal of Child Neurology
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Neurologic Findings in Children and Adults With Williams Syndrome

Catherine A. Chapman, MD

Department of Neurology, Children's Hospital and Harvard Medical School, Boston, MA

Adre du Plessis, MD

Department of Neurology, Children's Hospital and Harvard Medical School, Boston, MA

Barbara R. Pober, MD

Department of Genetics, Yale University School of Medicine, New Haven, CT

Twenty-four children with Williams syndrome underwent systematic neurologic evaluations. Abnormalities of mental status, motor coordination, tone, and gait were most prevalent. Tone abnormalities varied as a function of age, with younger children frequently exhibiting decreased tone and older subjects almost exclusively having increased tone. The gait and coordination abnormalities persisted among older subjects, indicating that they were not simply maturational problems. Physicians caring for such youngsters need to be aware that a variety of neurologic abnormalities are common in Williams syndrome and may change or progress over time. Neurologic examinations that reveal findings beyond the typical pattern that we report may raise suspicion for added neurologic insult and warrant further investigation. (J Child Neurol 1995;10:63-65).

Journal of Child Neurology, Vol. 11, No. 1, 63-65 (1996)
DOI: 10.1177/088307389601100116
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