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Journal of Child Neurology
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Neurologic Abnormalities in Infantile Autism

Richard H. Haas, MD

Department of Neurosciences School of Medicine, University of California San Diego, La Jolla, Department of Pediatrics School of Medicine, University of California San Diego, La Jolla

Jeanne Townsend, PhD

Department of Neurosciences School of Medicine, University of California San Diego, La Jolla, Autism and Brain Development Research Laboratory Children's Hospital, San Diego, CA

Eric Courchesne, PhD

Department of Neurosciences School of Medicine, University of California San Diego, La Jolla, Autism and Brain Development Research Laboratory Children's Hospital, San Diego, CA

Alan J. Lincoln, PhD

Autism and Brain Development Research Laboratory Children's Hospital, San Diego, CA

Laura Schreibman, PhD

Department of Psychology School of Medicine, University of California San Diego, La Jolla

Rachel Yeung-Courchesne, BS

Autism and Brain Development Research Laboratory Children's Hospital, San Diego, CA

Neuroanatomic, pathologic, and neurobehavioral studies point to a cerebellar and parietal abnormality in autism. We used a standardized protocol to examine neurologic function in 28 pediatric autistic subjects and 24 pediatric normal healthy volunteer controls. As a group, the autistic subjects had quantitative measures from magnetic resonance imaging suggesting hypoplasia or hyperplasia of the cerebellar vermis, as well as measurements of posterior corpus callosum suggesting abnormalities of posterior cortex. In groups of tests that reflect cerebellar and parietal function, the neurologic abnormalities detectable by clinical examination were significantly greater for autistic subjects than for normal controls. These studies confirm that the structural and behavioral deficit in autism does lead to abnormalities that can be detected on the clinical neurologic examination. (J Child Neurol 1996; 11:84-92).

Journal of Child Neurology, Vol. 11, No. 2, 84-92 (1996)
DOI: 10.1177/088307389601100204
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