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Severity of Medical and Neurologic Complications as a Determinant of Neurodevelopmental Outcome at 6 and 12 Months in Very Low Birth Weight Infants

Department of Neurology, Section of Neurophysiology, Cain Foundation Laboratories, Department of Pediatrics (Dr Anderson), Baylor College of Medicine, Houston

Susan R. Wildin, MD

Department of Pediatrics, Child Development University of Texas Medical Branch, Galveston

Marilyn Woodside, MD

Department of Neurology, Pediatric Neurology, University of Texas Health Science Center, Houston

Paul R. Swank, PhD

Department of Educational Psychology University of Houston, Houston, TX

Karen E. Smith, PhD

Department of Pediatrics, Child Development University of Texas Medical Branch, Galveston

Susan E. Denson, MD

Department of Pediatrics, Neonatology, University of Texas Health Science Center, Houston

Cynthia L. Miller, PhD

Developmental Pediatrics University of Texas Health Science Center, Houston

Ian J. Butler, MD

Department of Neurology, Pediatric Neurology, University of Texas Health Science Center, Houston

Susan H. Landry, PhD

Developmental Pediatrics University of Texas Health Science Center, Houston

Very low birth weight (n = 154) and term infants (n = 119) had neurologic and developmental assessment at 6 and 12 months of age. Preterm infants with severe neonatal complications were considered to be at high risk, and those with milder complications were considered to be at low risk, for neurodevelopmental abnormality. Compared to term infants, high- and low-risk infants had abnormalities at 6 months in total neurologic score, cranial nerves, motor tone, motor coordination, and reflexes (P < .001). At 12 months, all groups had improved. However, high-risk infants had persistent abnormalities in the same subcategories (P < .001), whereas low-risk infants differed from term infants only in motor tone (P < .001). Bayley developmental scores were different for all groups at 6 months (P < .001), but at 12 months only high-risk infants differed from term infants (P < .01). These results demonstrate improvement in neurologic and developmental scores over time in very low birth weight infants. The degree of neurodevelopmental abnormality and improvement over time is related to severity of neonatal complications in preterm infants. (J Child Neurol 1996;11:215-219).

Journal of Child Neurology, Vol. 11, No. 3, 215-219 (1996)
DOI: 10.1177/088307389601100311


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