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Journal of Child Neurology
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Low Levels of Nerve Growth Factor in Cerebrospinal Fluid of Children With Rett Syndrome

Raija Lappalainen, MD

From the Department of Child Neurology, Children's Castle Hospital, Helsinki, Finland

Dan Lindholm, PhD

Department of Developmental Neuroscience, Uppsala University, Biomedical Center, BOX 587, S-75123 Uppsala, Sweden

Raili Riikonen, PhD

Department of Child Neurology, University Central Hospital, Helsinki, Finland

A role for neurotrophic factors has been postulated in some human neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. The known developmental effects of these substances suggested that, in some neurologic diseases affecting children, neurotrophic factors might be inadequate. Using a sensitive, two-site enzyme-linked immunoassay, we examined the content of nerve growth factor in the cerebrospinal fluid of 11 children with Rett syndrome and of 24 control patients with various neurologic diagnoses or suffering from other diseases. Nerve growth factor levels were significantly lower in the cerebrospinal fluid of the patients with Rett syndrome than in control patients. The lower level of cerebrospinal fluid nerve growth factor in Rett syndrome suggests that lack of nerve growth factor may be involved in the pathogenesis of this disease or reflect the underlying brain damage present. (J Child Neurol 1996;11:296-300).

Journal of Child Neurology, Vol. 11, No. 4, 296-300 (1996)
DOI: 10.1177/088307389601100407
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