Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Legarda, S.B.
Right arrow Articles by Maria, B.L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Legarda, S.B.
Right arrow Articles by Maria, B.L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Altered Cognitive Functioning in Children With Idiopathic Epilepsy Receiving Valproate Monotherapy

S.B. Legarda, MD

Department of Pediatrics (Neurology), University of Florida, Gainesville, FL

M.P. Booth, PhD

Department of Clinical Health and Psychology, University of Florida, Gainesville, FL

E.B. Fennell, PhD

Department of Clinical Health and Psychology, University of Florida, Gainesville, FL

B.L. Maria, MD

Department of Pediatrics (Neurology), University of Florida, Gainesville, FL

Once a child is diagnosed with epilepsy, a primary concern is whether or not the child's behavior and cognitive abilities will be affected by the disease, by the drug prescribed for seizure control, or both. Direct cognitive effects by the epileptic condition have been described. On the other hand, cognitive effects in epilepsy have been attributed to antiepileptic drug therapy. Valproate is an antiepileptic drug of choice in managing the commonest childhood epilepsy syndromes. Although frequently prescribed in pediatric neurology practice, there have been relatively few studies investigating the cognitive effects of valproate therapy in children. Cognitive effects of valproate reported in normal adult volunteers and in adults with epilepsy cannot be generalized to the pediatric population. The results of investigations on children are less conclusive. Guidelines for antiepileptic drug trials in children have recently been formulated. Carefully designed studies are required in determining the cognitive effects of valproate in the pediatric population. Neuropsychological measures that are likely to assess subtle changes in higher brain functions crucial to learning in children should be employed. We propose a test battery to assess for cognitive changes associated with anticonvulsant therapy in children. (J Child Neurol 1996;11:321-330).

Journal of Child Neurology, Vol. 11, No. 4, 321-330 (1996)
DOI: 10.1177/088307389601100411
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 NeurologyHome page
G. M. Ronen, B. F. Meaney, C. Cunningham, P. Pavone, R. Bianchini, G. Incorpora, A. Pavone, E. Parano, and R. R. Trifiletti
Neuropsychological assessment in children with absence epilepsy
Neurology, November 27, 2001; 57(10): 1940 - 1940.
[Full Text] [PDF]

Home page
 NeurologyHome page
P. Pavone, R. Bianchini, R.R. Trifiletti, G. Incorpora, A. Pavone, and E. Parano
Neuropsychological assessment in children with absence epilepsy
Neurology, April 24, 2001; 56(8): 1047 - 1051.
[Abstract] [Full Text] [PDF]