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Head Circumference Measurements in Children With Autism

University Affiliated Cincinnati Center for Developmental Disorders, Children's Hospital Medical Center

Bonnie Patterson, MD

University Affiliated Cincinnati Center for Developmental Disorders, Children's Hospital Medical Center

Peter Gartside, PhD

University of Cincinnati College of Medicine Cincinnati, OH

To assess head circumference in children with autism, 148 charts were retrospectively reviewed. All of the children met the Diagnostic and Statistical Manual ofmental Disorders (DSM-III or DSM-III-R) criteria for autism and had no known underlying condition that might affect head circumference. In addition, data were collected regarding height, weight, brain imaging, cognitive development, adaptive behavior, and language. The children were divided into two groups: those with head circumference at or above the 98th percentile (Group 1) and those with head circumference below the 98th percentile (Group 2). Group 1 consisted of 27 (18.2%) of the children. Height measurements were significantly higher in Group 1 as compared with Group 2 (P = .0006) as were weight measurements (P = .0003). Group 1 had a significantly lower percentage of females (P = .04) and lower adaptive behavior scores (P = .0067) than Group 2. Routine brain imaging studies could not explain the macrocephaly in Group 1. The etiology of large head circumference and increased growth indices in children with autism is unclear. (J Child Neurol 1996;11:389-393).

Journal of Child Neurology, Vol. 11, No. 5, 389-393 (1996)
DOI: 10.1177/088307389601100509


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