Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

http://mc.manuscriptcentral.com/childneurology

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Huggle, S.
Right arrow Articles by Sparks, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huggle, S.
Right arrow Articles by Sparks, D. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Oxidative Stress in Sudden Infant Death Syndrome

Stefanie Huggle

Sanders-Brown Center on Aging, and Department of Pathology, University of Kentucky Medical Center, Division of Medical Examiner's Services, Kentucky Justice Cabinet, Lexington, KY

John C. Hunsaker, MD, JD

Sanders-Brown Center on Aging, and Department of Pathology, University of Kentucky Medical Center, Division of Medical Examiner's Services, Kentucky Justice Cabinet, Lexington, KY

Carolyn M. Coyne, MD

Sanders-Brown Center on Aging, and Department of Pathology, University of Kentucky Medical Center, Division of Medical Examiner's Services, Kentucky Justice Cabinet, Lexington, KY

D. Larry Sparks, PhD

Sanders-Brown Center on Aging, and Department of Pathology, University of Kentucky Medical Center, Division of Medical Examiner's Services, Kentucky Justice Cabinet, Lexington, KY

We investigated the hippocampus and parahippocampal cortex of victims of sudden infant death syndrome and of age-matched infants dying acutely of known causes (non-sudden infant death syndrome controls). Tissue sections were investigated for the presence of neurons expressing signs of elevated levels of free radical using immunohistochemical markers for superoxide dismutase and glutathione peroxidase. Brain tissues displayed immunopositive neurons in every infant. In control infants, an age-related decline in the number of superoxide dismutase- and glutathione peroxidase-immunoreactive neurons was apparent in the hippocampus and parahippocampal cortex. Significantly increased numbers of immunoreactive neurons were found in victims of sudden infant death syndrome under 6 months of age compared to age-matched controls. This suggests that infants who later become victims of sudden infant death syndrome may experience antemortem periods of oxidative stress, elevated levels of free radicals, and compensatory up-regulation of the free radical scavenger enzymes superoxide dismutase and glutathione peroxidase. (J Child Neurol 1996; 11:433-438).

Journal of Child Neurology, Vol. 11, No. 6, 433-438 (1996)
DOI: 10.1177/088307389601100603
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
D. K. Mulkey, R. A. Henderson III, N. A. Ritucci, R. W. Putnam, and J. B. Dean
Oxidative stress decreases pHi and Na+/H+ exchange and increases excitability of solitary complex neurons from rat brain slices
Am J Physiol Cell Physiol, April 1, 2004; 286(4): C940 - C951.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. B. Dean, D. K. Mulkey, R. A. Henderson III, S. J. Potter, and R. W. Putnam
Hyperoxia, reactive oxygen species, and hyperventilation: oxygen sensitivity of brain stem neurons
J Appl Physiol, February 1, 2004; 96(2): 784 - 791.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. K. Mulkey, R. A. Henderson III, R. W. Putnam, and J. B. Dean
Hyperbaric oxygen and chemical oxidants stimulate CO2/H+-sensitive neurons in rat brain stem slices
J Appl Physiol, September 1, 2003; 95(3): 910 - 921.
[Abstract] [Full Text] [PDF]