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Journal of Child Neurology
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Expression of HLA Class I Antigens in Skeletal Muscle Is a Diagnostic Marker in Juvenile Dermatomyositis

Haluk Topaloglu, MD

Neuromuscular Unit, Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, London, UK

Francesco Muntoni, MD

Neuromuscular Unit, Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, London, UK

Victor Dubowitz, MD, PhD, FRCP, DCH

Neuromuscular Unit, Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, London, UK

Caroline Sewry, PhD

Muscle Cell Biology Group, MRC Clinical Sciences Centre Royal Postgraduate Medical School, London, UK

HLA class I gene products are immunocytochemically detectable in the skeletal muscle of many patients with inflammatory conditions. We report three cases of juvenile dermatomyositis with minimal histologic abnormalities and no inflammation in the muscle biopsies. All three showed strong expression of HLA class I antigens on muscle fibers. Analysis of HLA class I expression is thus a useful marker for the diagnosis of inflammatory muscle disease, even in the absence of histologic changes. (J Child Neurol 1997;12:60-63).

Journal of Child Neurology, Vol. 12, No. 1, 60-63 (1997)
DOI: 10.1177/088307389701200111
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[Abstract] [Full Text]