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Journal of Child Neurology
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Meeting the Challenge of Epilepsy in Persons With Multiple Handicaps

Theodore R. Sunder, MD

Southern Illinois University School of Medicine, and Illinois Department of Human Services, Office of Developmental Disabilities, Springfield, IL

Epilepsy occurs in more than 30% of persons with mental retardation and up to 50% of those with multiple handicaps living in institutional settings. Treatment of epilepsy in this population presents many unique challenges. Through careful adherence to basic principles of diagnosis, classification, and antiepileptic drug use, as many as 80% of individuals can be successfully managed with one- or two-drug therapy and enjoy positive outcomes in the areas of community integration and increased independence. Rational polypharmacy with the newer anticonvulsant drugs offers additional opportunity for improving outcomes for these individuals, especially with the use of felbamate and lamotrigine, where broad-spectrum efficacy and positive impact on psychosocial functioning is being demonstrated. Further systematic study of new drugs in this population is clearly warranted. ( J Child Neurol 1997;12(Suppl 1):S38-S43).

Journal of Child Neurology, Vol. 12, No. 1 Suppl, S38-S43 (1997)
DOI: 10.1177/0883073897012001091
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This article has been cited by other articles:


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J. R. McKee, T. R. Sunder, A. Vuong, and A. E. Hammer
Adjunctive Lamotrigine for Refractory Epilepsy in Adolescents with Mental Retardation
J Child Neurol, May 1, 2006; 21(5): 372 - 379.
[Abstract] [PDF]


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