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Journal of Child Neurology
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Behavioral and Cognitive Effects of Lamotrigine

Kimford J. Meador, MD

Department of Neurology, Medical College of Georgia, Augusta, GA

Gus A. Baker, PhD

Walton Centre for Neurology & Neurosurgery NHS Trust, Liverpool, United Kingdom

Lamotrigine is a new antiepileptic drug that may possess unique cognitive and behavioral characteristics. Although lamotrigine can produce neurobehavioral toxicity, it is generally well tolerated. In one study directly comparing lamotrigine to placebo as add-on therapy in patients with intractable epilepsy, no objective cognitive effects were observed in a limited neuropsychological battery. Several studies have demonstrated favorable effects of lamotrigine on psychological well-being that were not explained by simple effects on seizure frequency and severity. In direct comparisons with carbamazepine and phenytoin, lamotrigine has been reported to produce positive effects on quality of life scales of patient perception. In addition, positive behavioral effects have also been observed in two blinded studies and several open trials for patients with severe mental disability and refractory epilepsy. Future studies with more extensive neuropsychological assessments are needed to delineate the differential cognitive and behavioral effects of lamotrigine in epilepsy and psychiatric disorders. (J Child Neurol 1997;12(Suppl 1):S44-S47).

Journal of Child Neurology, Vol. 12, No. 1 Suppl, S44-S47 (1997)
DOI: 10.1177/0883073897012001101
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This article has been cited by other articles:


Home page
 J Child NeurolHome page
J. R. McKee, T. R. Sunder, A. Vuong, and A. E. Hammer
Adjunctive Lamotrigine for Refractory Epilepsy in Adolescents with Mental Retardation
J Child Neurol, May 1, 2006; 21(5): 372 - 379.
[Abstract] [PDF]


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