This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Suzaki, I. Articles by Takeshita, K. Search for Related Content PubMed PubMed Citation Articles by Suzaki, I. Articles by Takeshita, K. Social Bookmarking                         What's this?

Nerve Growth Factor Levels in Cerebrospinal Fluid From Patients With Neurologic Disorders

Division of Child Neurology, Institute of Neurological Sciences, Tottori University School of Medicine

Toshiro Hara, MD

Division of Child Neurology, Institute of Neurological Sciences, Tottori University School of Medicine

Yoshihiro Maegaki, MD

Division of Child Neurology, Institute of Neurological Sciences, Tottori University School of Medicine

Sakae Narai, MD

Division of Pediatrics, Tottori Prefectural Kosei Hospital, Tottori, Japan

Kenzo Takeshita, MD

Division of Child Neurology, Institute of Neurological Sciences, Tottori University School of Medicine

Nerve growth factor levels were measured in the cerebrospinal fluid from 73 patients with neurologic disorders and non-neurologic acute illnesses by a two-site enzyme immunoassay. Elevated nerve growth factor levels in cerebrospinal fluid were demonstrated in 2 of 7 patients with bacterial meningitis, 7 of 14 patients with viral meningitis or encephalitis, and 1 with multiple sclerosis. Follow-up examinations of the 3 patients (1 with bacterial meningitis, 1 with viral meningitis, and 1 with multiple sclerosis) at convalescent stage showed diminished nerve growth factor levels in cerebrospinal fluid. None of the other patients showed elevation of nerve growth factor levels in cerebrospinal fluid. Nerve growth factor levels in cerebrospinal fluid were not correlated with cell numbers in patients with meningitis or encephalitis. No relationship was observed between nerve growth factor levels and outcome in patients with viral meningitis or encephalitis and bacterial meningitis. Nerve growth factor in cerebrospinal fluid may play a role in neuronal recovery or function as an immunomodulator in children with inflammatory and immune-mediated neurologic disorders. (J Child Neurol 1997; 12:205-207).

Journal of Child Neurology, Vol. 12, No. 3, 205-207 (1997)
DOI: 10.1177/088307389701200310


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				P. J. Owen-Lynch, C. E. Draper, F. Mashayekhi, C. M. Bannister, and J. A. Miyan Defective cell cycle control underlies abnormal cortical development in the hydrocephalic Texas rat Brain, March 1, 2003; 126(3): 623 - 631. [Abstract] [Full Text] [PDF]

				F. Mashayekhi, C. E. Draper, C. M. Bannister, M. Pourghasem, P. J. Owen-Lynch, and J. A. Miyan Deficient cortical development in the hydrocephalic Texas (H-Tx) rat: a role for CSF Brain, August 1, 2002; 125(8): 1859 - 1874. [Abstract] [Full Text] [PDF]

				R. Vanhala, L. Korhonen, M. Mikelsaar, D. Lindholm, and R. Riikonen Neurotrophic Factors in Cerebrospinal Fluid and Serum of Patients With Rett Syndrome J Child Neurol, September 1, 1998; 13(9): 429 - 433. [Abstract] [PDF]