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Journal of Child Neurology
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Treatment of Children With Williams Syndrome With Methylphenidate

Harry N. Bawden, PhD

Department of Psychology, IWK-Grace Health Centre, and Dalhousie University, Halifax, NS, Canada, Department of Pediatrics IWK-Grace Health Centre, and Dalhousie University, Halifax, NS, Canada

G. Wayne MacDonald, PhD

Department of Psychology, IWK-Grace Health Centre, and Dalhousie University, Halifax, NS, Canada, Department of Pediatrics IWK-Grace Health Centre, and Dalhousie University, Halifax, NS, Canada

Sarah Shea, MD

Department of Pediatrics IWK-Grace Health Centre, and Dalhousie University, Halifax, NS, Canada

Children with Williams syndrome frequently present with symptoms of attention deficit hyperactivity disorder (ADHD), but there is little information that stimulant medication is useful in this population. A series of double-blind, placebo-controlled case studies was used to evaluate the cognitive and behavioral effects of methylphenidate on four children with Williams syndrome. Teachers and mothers completed behavioral rating scales and cognitive tests of attention, learning and memory, and academic productivity and accuracy in mathematics in each medication condition. Two of the children responded favorably in terms of decreased impulsivity, decreased irritability, and lower activity level as well as improved ability to pay attention. Methylphenidate is a useful adjunct in the treatment of some children with Williams syndrome. (J Child Neurol 1997;12:248—252).

Journal of Child Neurology, Vol. 12, No. 4, 248-252 (1997)
DOI: 10.1177/088307389701200405
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