This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Korenke, G. C. Articles by Hanefeld, F. Search for Related Content PubMed PubMed Citation Articles by Korenke, G. C. Articles by Hanefeld, F. Pubmed/NCBI databases Substance via MeSH Genetics Home Reference Genetics Home Reference - ABCD1 Gene Genetics Home Reference - X-linked adrenoleukodystrophy Social Bookmarking                         What's this?

Inthrathecal IgA Synthesis in X-Linked Cerebral Adrenoleukodystrophy

Department of Paediatrics and Neuropaediatrics

Hansotto Reiber, PhD

Neurochemisches Labor, Department of Neurology, University of Göttingen, Germany

Donald H. Hunneman, PhD

Department of Paediatrics and Neuropaediatrics

Folker Hanefeld, MD

Department of Paediatrics and Neuropaediatrics

Cerebrospinal fluid data of 25 patients suffering from various phenotypes of X-linked adrenoleukodystrophy have been evaluated neurochemically including cerebrospinal fluid/serum quotient diagrams. Intrathecal IgA production in 13 of 14 patients with cerebral adrenoleukodystrophy was the most sensitive parameter in cerebrospinal fluid and was not seen in any of the neurologically asymptomatic patients or in the patients with adrenomyeloneuropathy. A blood-cerebrospinal fluid barrier dysfunction was found in 9 of these 14 patients. Additional intrathecal IgG or IgM synthesis was observed in 3 patients each. In 1 patient with lumbar punctures before and after onset of neurologic symptoms intrathecal IgA synthesis was seen only after the appearance of neurologic symptoms. Repetition of lumbar punctures in 5 neurologically symptomatic patients with cerebral adrenoleukodystrophy revealed a similar pattern of intrathecal IgA synthesis with a tendency to decreasing IgA concentration. The pathophysiologic aspects of intrathecal IgA synthesis are discussed in relation to other demyelinating and inflammatory neurologic diseases. (J Child Neurol 1997;12:314-320).

Journal of Child Neurology, Vol. 12, No. 5, 314-320 (1997)
DOI: 10.1177/088307389701200505


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				A. J. Dorta-Contreras and H. Reiber Intrathecal Synthesis of Immunoglobulins in Eosinophilic Meningoencephalitis Due to Angiostrongylus cantonensis Clin. Vaccine Immunol., July 1, 1998; 5(4): 452 - 455. [Abstract] [Full Text] [PDF]

				H. Reiber Cerebrospinal fluid - physiology, analysis and interpretation of protein patterns for diagnosis of neurological diseases Multiple Sclerosis, June 1, 1998; 4(3): 99 - 107. [Abstract] [PDF]