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Somatosensory Evoked Magnetic Fields From Primary Sensorimotor Cortex in Juvenile Neuronal Ceroid Lipofuscinosis

Children's Hospital, Pediatric Neurology, University of Helsinki and the Department of Radiology

Erika Heikkilä, BM

Children's Hospital, Pediatric Neurology

Taina Autti, MD, PhD

Children's Hospital, Pediatric Neurology

Kimmo Sainio, MD, PhD

Children's Hospital, Pediatric Neurology

Juha Huttunen, MD, PhD

BioMag Laboratory, Medical Engineering Centre Helsinki University Central Hospital, Helsinki, Finland

Hannu J. Aronen, MD, PhD

University of Helsinki and the Department of Radiology

Antti Korvenoja, MD

University of Helsinki and the Department of Radiology

Risto J. Ilmoniemi, PhD

BioMag Laboratory, Medical Engineering Centre Helsinki University Central Hospital, Helsinki, Finland

Pirkko Santavuori, MD, PhD

Children's Hospital, Pediatric Neurology

The present study evaluated neurophysiologic function of the primary sensorimotor cortex in juvenile neuronal ceroid lipofuscinosis. A 122-channel magnetometer, which allowed studies of the somatosensory system in millimeter and millisecond precision, was used to record somatosensory evoked magnetic fields to median nerve stimulation from 10 patients and their matched control subjects. In both patients and controls, the somatosensory evoked magnetic fields from primary sensorimotor area typically consisted of N20m, P35m, and P60m deflections. In the patients, N20m was significantly delayed, whereas P35m peaked earlier than in the control subjects. The source strengths for N20m and P35m were greater in the patients than in the controls. Both deflections showed a significant positive correlation with the disease duration: the sources were stronger in the older patients than in the younger ones. P60m deflections were normal or reduced in the patients. The results indicated increased thalamocortical excitability in the sensorimotor cortex in juvenile neuronal ceroid lipofuscinosis. (J Child Neurol 1997;12:355-360).

Journal of Child Neurology, Vol. 12, No. 6, 355-360 (1997)
DOI: 10.1177/088307389701200603


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