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Journal of Child Neurology
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Alpha-Interferon in the Treatment of Subacute Sclerosing Panencephalitis

Michel N. Fayad, MD

Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon

Bassem I. Yamout, MD

Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

Salman Mroueh, MD

Department of Pediatrics, American University of Beirut Medical Center, Beirut, Lebanon

Subacute sclerosing panencephalitis is an inexorably progressive disease with no effective therapy. Recent trials of intrathecal and intraventricular alpha-interferon yielded controversial results. We tried intrathecal or intraventricular alpha-interferon in four patients with subacute sclerosing panencephalitis. None of them had evidence of improvement. We reviewed the previously published studies on the use of alpha-interferon in subacute sclerosing panencephalitis. Further international collaborative studies are needed to determine the role of alpha-interferon in the treatment of subacute sclerosing panencephalitis. (J Child Neurol 1997; 12:486-488).

Journal of Child Neurology, Vol. 12, No. 8, 486-488 (1997)
DOI: 10.1177/088307389701200803
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