This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Seri, S. Articles by Curatolo, P. Search for Related Content PubMed PubMed Citation Articles by Seri, S. Articles by Curatolo, P. Social Bookmarking                         What's this?

Frontal Lobe Epilepsy Associated With Tuberous Sclerosis: Electroencephalographic-Magnetic Resonance Image Fusioning

Department of Child Neurology and Psychiatry, University "La Sapienza," Rome

Antonella Cerquiglini, MD

Department of Child Neurology and Psychiatry, University "La Sapienza," Rome

Francesco Pisani, MD

Department of Child Neurology and Psychiatry, University "La Sapienza," Rome

Christoph M. Michel, PhD

Department of Neurology, Hopital Cantonale Universitaire, Génève

Roberto D. Pascual Marqui, PhD

"Key Institute for Mind-Brain Research," Department of Psychiatry, University of Zürich, Switzerland

Paolo Curatolo, MD

Department of Pediatric Neurology, University "Tor Vergata," Rome, and IRCCS "S. Lucia", Rome, Italy

We studied the topographic relationships between cortical and subcortical lesions shown on magnetic resonance images (MRI) and sources of epileptiform activity in a series of nine children with intractable epilepsy and tuberous sclerosis complex. Although video-electroencephalographic (EEG) monitoring was suggestive of a frontal seizure onset, interictal EEG was, in seven of nine cases, in the form of apparently bisynchronous discharges. In all cases, the use of a short time lag estimation procedure based on a nonlinear correlation function between surface recorded EEG signals allowed the detection of a lateralized onset of EEG paroxysmal activity. Furthermore, a computerized method based on a source localization EEG-MRI image fusioning procedure, has revealed a topographic concordance between well-defmed frontal cortical lesions shown on MRI and site of onset of paroxysmal discharges. Lennox-like EEG patterns frequently reported in children with tuberous sclerosis complex could be the result of the tendency of frontal tubers to induce secondary bilateral synchrony, with implications in the medical and eventually surgical management of the often drug-resistant associated seizures. (J Child Neurol 1998;13:33-38).

Journal of Child Neurology, Vol. 13, No. 1, 33-38 (1998)
DOI: 10.1177/088307389801300106


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R. Borgatti, C. Zucca, P. Piccinelli, H. Fondazione Macchi, L. Radice, A. Tofani, R. Benti, and F. Triulzi Unilateral Periventricular Nodular Heterotopia Associated With Diffuse Areas of Cerebral Functional Abnormalities J Child Neurol, September 1, 2000; 15(9): 622 - 626. [Abstract] [PDF]

				Baron and A. Barkovich MR Imaging of Tuberous Sclerosis in Neonates and Young AJNR Am. J. Neuroradiol., May 1, 1999; 20(5): 907 - 916. [Abstract] [Full Text]