This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Rho, J. M. Articles by Chugani, H. T. Search for Related Content PubMed PubMed Citation Articles by Rho, J. M. Articles by Chugani, H. T. Social Bookmarking                   What's this?

Alternating Hemiplegia of Childhood: Insights Into Its Pathophysiology

Departments of Neurology and Pediatrics, University of Washington School of Medicine, Children's Hospital and Medical Center, Seattle, Washington

Harry T. Chugani, MD

Departments of Neurology, Pediatrics, and Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan

Alternating hemiplegia of childhood is a rare disorder characterized by episodic paroxysmal attacks of neurologic dysfunction and has historically been thought to represent a migraine equivalent, an unusual form of epilepsy, or a movement disorder. Medical treatment with a variety of anticonvulsants and migraine agents is largely unsuccessful, and progressive mental deterioration is universally expected. Despite extensive laboratory studies, the pathophysiologic basis of this condition has thus far eluded identification. Recently, an international workshop was held to generate testable hypotheses regarding the pathophysiology of alternating hemiplegia of childhood. This paper summarizes the major proceedings of that workshop, and hopes to stimulate further interest in elucidating the molecular and cellular mechanisms underlying this unusual disorder. (J Child Neurol 1998;13:39-45).

Journal of Child Neurology, Vol. 13, No. 1, 39-45 (1998)
DOI: 10.1177/088307389801300107


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. T. Sweney, K. Silver, M. Gerard-Blanluet, J.-M. Pedespan, F. Renault, A. Arzimanoglou, M. Schlesinger-Massart, A. J. Lewelt, S. P. Reyna, and K. J. Swoboda Alternating Hemiplegia of Childhood: Early Characteristics and Evolution of a Neurodevelopmental Syndrome Pediatrics, March 1, 2009; 123(3): e534 - e541. [Abstract] [Full Text] [PDF]

				S. Auvin, S. Joriot-Chekaf, J. C. Cuvellier, F. Pandit, J. M. Cuisset, M. M. Ruchoux, and L. Vallee Small vessel abnormalities in alternating hemiplegia of childhood: Pathophysiologic implications Neurology, February 28, 2006; 66(4): 499 - 504. [Abstract] [Full Text] [PDF]

				M T Bassi, N Bresolin, A Tonelli, K Nazos, F Crippa, C Baschirotto, C Zucca, A Bersano, D Dolcetta, F M Boneschi, et al. A novel mutation in the ATP1A2 gene causes alternating hemiplegia of childhood J. Med. Genet., August 1, 2004; 41(8): 621 - 628. [Full Text] [PDF]

				Z. Pfund, D. C. Chugani, O. Muzik, C. Juhasz, M. E. Behen, J. Lee, P. Chakraborty, T. Mangner, and H. T. Chugani {alpha}[ 11C]Methyl-L-Tryptophan Positron Emission Tomography in Patients With Alternating Hemiplegia of Childhood J Child Neurol, April 1, 2002; 17(4): 253 - 260. [Abstract] [PDF]