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Journal of Child Neurology
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β-Interferon Plus Inosiplex in the Treatment of Subacute Sclerosing Panencephalitis

Banu Anlar, MD

Hacettepe University Department of Pediatric Neurology

Kalbiye Yalaz, MD

Hacettepe University Department of Pediatric Neurology

Gülsen Köse, MD

SSK Social Security Hospital Ankara, Turkey

Serap Saygi, MD

Department of Neurology

We treated seven patients with subacute sclerosing panencephalitis with β-interferon and oral inosiplex for 2 to 15 months. Stabilization or improvement was observed in three patients. The effect of treatment was equivocal in two other patients who became stable. The disease continued its progression in the remaining two patients who died. Treatment shorter than 2 months was not effective. Changes in electroencephalograms (EEG), magnetic resonance images (MRI), or cerebrospinal fluid measles antibody levels did not have a close correlation with clinical course. These results suggest that β-interferon might be efficient in some patients with subacute sclerosing panencephalitis and justify its trial in larger studies with longer follow-up. (J Child Neurol 1998; 13:557-559).

Journal of Child Neurology, Vol. 13, No. 11, 557-559 (1998)
DOI: 10.1177/088307389801301106
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