This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Pellock, J. M. Search for Related Content PubMed PubMed Citation Articles by Pellock, J. M. Social Bookmarking                         What's this?

Topical Review: Use of Midazolam for Refractory Status Epilepticus in Pediatric Patients

Division of Child Neurology, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA

Status epilepticus is more common among children than young adults. Children might be less likely to die and might be resistant to permanent neurologic damage due to status epilepticus, but significant sequelae also have been demonstrated. Aggressive intervention and rapid termination of seizures contribute significantly to better prognosis and reduced mortality from status epilepticus. Initial treatment of status epilepticus typically consists of either diazepam or lorazepam, immediately followed by phenytoin or phenobarbital. However, approximately 10% to 15% of status epilepticus episodes are refractory to these conventional therapies. Traditionally, refractory status epilepticus is treated with barbiturate coma or general anesthetics, both of which require invasive cardiorespiratory and hemodynamic monitoring and are associated with significant complications. Midazolam is a water-soluble benzodiazepine with a fast onset of action, a short half-life, and inactive metabolites that has been very effective in terminating seizures refractory to diazepam, lorazepam, phenytoin, and phenobarbital in pediatric patients. Midazolam is a valuable treatment option for refractory status epilepticus, especially in pediatric patients. (J Child Neurol 1998;13:581-587).

Journal of Child Neurology, Vol. 13, No. 12, 581-587 (1998)
DOI: 10.1177/088307389801301201


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. C. D. Brevoord, K. F. M. Joosten, W. F. M. Arts, R. W. van Rooij, and M. de Hoog Status Epilepticus: Clinical Analysis of a Treatment Protocol Based on Midazolam and Phenytoin J Child Neurol, June 1, 2005; 20(6): 476 - 481. [Abstract] [PDF]

				J. C. D. Brevoord, K. F. M. Joosten, W. F. M. Arts, R. W. van Rooij, and M. de Hoog Status Epilepticus: Clinical Analysis of a Treatment Protocol Based on Midazolam and Phenytoin J Child Neurol, June 1, 2005; 20(6): 476 - 481. [Abstract] [PDF]

				L. Blumkin, T. Lerman-Sagie, T. Houri, E. Gilad, A. Nissenkorn, M. Ginsberg, and N. Watemberg Pediatric Refractory Partial Status Epilepticus Responsive to Topiramate J Child Neurol, March 1, 2005; 20(3): 239 - 241. [Abstract] [PDF]

				J. S. Rotenberg and J. Newmark Nerve Agent Attacks on Children: Diagnosis and Management Pediatrics, September 1, 2003; 112(3): 648 - 658. [Abstract] [Full Text] [PDF]

				S. J. Parsons, K. Tomas, and P. Cox Review of a Large Clinical Series: Outcome of Pediatric Status Epilepticus Admitted to Intensive Care J Intensive Care Med, July 1, 2002; 17(4): 174 - 179. [Abstract] [PDF]

				S. Singhi, A. Murthy, P. Singhi, and M. Jayashree Continuous Midazolam Versus Diazepam Infusion for Refractory Convulsive Status Epilepticus J Child Neurol, February 1, 2002; 17(2): 106 - 110. [Abstract] [PDF]

				D. L. Gilbert, P. S. Gartside, and T. A. Glauser Efficacy and Mortality in Treatment of Refractory Generalized Convulsive Status Epilepticus in Children: A Meta-Analysis J Child Neurol, September 1, 1999; 14(9): 602 - 609. [Abstract] [PDF]