This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Taylor, H. G. Articles by Michaels, R. H. Search for Related Content PubMed PubMed Citation Articles by Taylor, H. G. Articles by Michaels, R. H. Social Bookmarking                   What's this?

Acute-Phase Neurologic Complications of Haemophilus Influenzae Type b Meningitis: Association With Developmental Problems at School Age

Department of Pediatrics, Case Western Reserve University School of Medicine and Rainbow Babies and Childrens Hospital

Christopher Schatschneider, PhD

Department of Psychology, University of Houston

Gordon V. Watters, MD

Department of Pediatrics, Montreal Children's Hospital

Elaine L. Mills, MD

Department of Pediatrics, Montreal Children's Hospital

Ronald Gold, MD

Department of Pediatrics, Hospital for Sick Children

Noni MacDonald, MD

Department of Pediatrics, Children's Hospital of Eastern Ontario

Richard H. Michaels, MD

Department of Pediatrics, Children's Hospital of Pittsburgh

The purposes of this study were to describe the incidence of acute-phase neurologic complications in a sample of 126 children with Haemophilus influenzae type b meningitis, and to determine if these complications were associated with higher rates of learning and behavior problems at school age. Risks were assessed by comparing rates of adverse psychoeducational outcomes in the 53 children in the sample with complications to corresponding outcome rates in the 67 children who were free of neurologic complications and who did not have abnormal electroencephalograms (EEGs) or computed tomographic (CT) scans. Comparisons were made by means of logistic regression analysis. Twenty-nine children (23% of the sample) had seizures, 16 (13%) were comatose or obtunded, 15 (12%) had sensorineural hearing loss, 8 (6%) had hemiparesis, and 7 (6%) had cranial nerve deficits other than hearing loss. Relative to children without complications, those with complications had higher rates of grade repetition and substandard performance on neuropsychological and achievement testing. Adverse outcomes, however, consisted primarily of more subtle cognitive and learning problems; only two of the children in the sample obtained prorated IQ scores below 70. Sequelae were associated with persistent neurologic deficits and bilateral hearing loss, as well as with transient symptoms including seizures, coma, and hemiparesis. While study findings argue against adverse consequences for the vast majority of children treated for this disease, the results clarify learning and behavior outcomes and indicate which children are at greatest risk. (J Child Neurol 1997;13:113-119).

Journal of Child Neurology, Vol. 13, No. 3, 113-119 (1998)
DOI: 10.1177/088307389801300304


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				P. R. Dodge, M. Scaer, S. J. Holmes, S. L. Pomeroy, and R. D. Feigin Psychometric Testing in Bacterial Meningitis: Results of a Long-Term Prospective Study of Infants and Children Treated Between 1973 and 1977 J Child Neurol, November 1, 2001; 16(11): 854 - 857. [Abstract] [PDF]