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Lamotrigine Treatment in Childhood Drug Resistant Epilepsy

Institute of Clinical Pediatrics, University of Siena, Italy

Salvatore Grosso, MD

Institute of Clinical Pediatrics, University of Siena, Italy

Alberto Fois, MD

Institute of Clinical Pediatrics, University of Siena, Italy

The clinical response to lamotrigine has been evaluated in a group of 63 drug resistant epileptic children in an open add-on trial. A negative response was observed in 30 subjects. In 11 patients, after an initial improvement lasting a mean period of 8 months, seizures recurred with the same frequency present before the beginning of the treatment. Twenty-two patients responded to lamotrigine treatment. Period of observation in the responsive group ranged from 1 year to 3 years. Response was complete in 16 patients and in the other 6 a 50% to 90% decrease of seizures was obtained. A complete normalization of the electroencephalogram (EEG) was registered in 10 cases after a mean period of 5 months of therapy. Side effects were mild and limited to 12 patients. Improvement was obtained in social and academic performance. Writing ability improved in one case. Lamotrigine can be considered a useful drug in the therapeutic armamentarium for childhood drug resistant epilepsy. (J Child Neurol 1998;13:163-167).

Journal of Child Neurology, Vol. 13, No. 4, 163-167 (1998)
DOI: 10.1177/088307389801300403


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