This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Holopainen, I. E. Articles by Sillanpää, M. Search for Related Content PubMed PubMed Citation Articles by Holopainen, I. E. Articles by Sillanpää, M. Social Bookmarking                         What's this?

Abnormal Frequency Mismatch Negativity in Mentally Retarded Children and in Children With Developmental Dysphasia

Department of Pediatric Neurology University Hospital of Turku

Pirjo Korpilahti, PhD

Centre for Cognitive Neuroscience, University of Turku, Turku, Finland

Kirsi Juottonen, MD

Centre for Cognitive Neuroscience, University of Turku, Turku, Finland

Heikki Lang, MD, PhD

Department of Clinical Neurophysiology University Hospital of Turku, University of Turku, Turku, Finland

Matti Sillanpää, MD, PhD

Department of Pediatric Neurology University Hospital of Turku

The auditory event-related potential waveform termed "mismatch negativity" was examined in 12 mentally retarded children with delayed development of speech and language (aged 5-8 years) and in 13 children with developmental dysphasia (aged 5-9 years). The mismatch negativity waves were elicited with pure sine-wave tone stimuli using the oddball paradigm. We measured the peak latency and peak amplitude of mismatch negativity responses to frequency (500/553 Hz) difference. The mismatch negativity patterns were compared with those of 10 children with normal development of linguistic skills (aged 5-9 years). In both the mentally retarded and dysphasic groups, the peak amplitude of the frequency mismatch negativity was significantly attenuated when compared with the control group, but no significant difference was observed between the mentally retarded and dysphasic groups. Attenuated frequency mismatch negativity was related to impairment of linguistic skills irrespective of the child's cognitive skills. Because the mismatch negativity response reflects central auditory processing and is modal specific for auditory stimuli, this change-specific response can serve as an objective tool to elucidate central auditory deficits in children. (J Child Neurol 1998;13:178-183).

Journal of Child Neurology, Vol. 13, No. 4, 178-183 (1998)
DOI: 10.1177/088307389801300406


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				E. Pihko, A. Mickos, T. Kujala, A. Pihlgren, M. Westman, P. Alku, R. Byring, and M. Korkman Group Intervention Changes Brain Activity in Bilingual Language-Impaired Children Cereb Cortex, April 1, 2007; 17(4): 849 - 858. [Abstract] [Full Text] [PDF]

				N. L. Antunes Topical Review: Acute Neurologic Complications in Children With Systemic Cancer J Child Neurol, November 1, 2000; 15(11): 705 - 716. [Abstract] [PDF]