This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Evers, S. Articles by Husstedt, I.-W. Search for Related Content PubMed PubMed Citation Articles by Evers, S. Articles by Husstedt, I.-W. Pubmed/NCBI databases Medline Plus Health Information Headache Migraine Social Bookmarking                         What's this?

Event-Related Potentials (P300) in Primary Headache in Childhood and Adolescence

Department of Neurology, University of Munster, Munster, Germany

Birgit Bauer, MD

Department of Neurology, University of Munster, Munster, Germany

Karl-H. Grotemeyer, MD

Department of Neurology, University of Munster, Munster, Germany

Gerd Kurlemann, MD

Department of Neuropediatrics University of Munster, Münster, Germany

Ingo-W. Husstedt, MD

Department of Neurology, University of Munster, Munster, Germany

There is strong evidence for a loss of habituation during cognitive processing in migraine as measured by P300 and contingent negative variation in adults. Event-related potentials evoked by an oddball paradigm have not yet been studied in children and adolescents suffering from different primary headache types. We recorded visually evoked event-related potentials (two consecutive trials, 200 stimuli each) in 48 children and adolescents suffering from migraine without or with aura, from episodic tension-type headache, and from ergotamine-induced headache and analyzed the latencies, amplitudes, and reaction times. No statistically significant differences were noted between all headache types and healthy controls analyzing the averaged parameters for the whole measurement. However, a highly significant loss of cortical habituation as measured by P300 amplitude and latency could be observed in migraine without and with aura by analyzing the first and the second trial of measurement separately. This phenomenon increased with age and could not be seen in healthy controls, or patients with tension-type headache or ergotamine-induced headache. Our data suggest a specific cognitive processing in migraine even in children and adolescents. Measurement of the habituation effect in P300 latency and amplitude provides a specific method to differentiate between primary headache types in childhood and adolescence. (J Child Neurol 1998;13:322-326).

Journal of Child Neurology, Vol. 13, No. 7, 322-326 (1998)
DOI: 10.1177/088307389801300703


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. Ryan Medicines for migraine Arch. Dis. Child. Ed. Pract., April 1, 2007; 92(2): ep50 - ep55. [Full Text] [PDF]