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Proton Magnetic Resonance Spectroscopy in Children With Sturge-Weber Syndrome

Department of Psychiatry and Behavioral Neurosciences, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI

Thomas L. Slovis, MD

Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, Department of Pediatrics Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI

Harry T. Chugani, MD

Department of Radiology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, Department of Neurology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, Department of Pediatrics Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI

Quantitative proton magnetic resonance spectroscopy was performed on six children with Sturge-Weber syndrome following gadolinium enhanced magnetic resonance imaging (MRI). MRI revealed only unilateral involvement in all cases. The mean concentration (mmol/kg wet weight) of the neuronal marker N-acetyl-aspartate was significantly reduced by 37% in the ipsilateral gadolinium enhanced volume of interest compared to a similarly placed contralateral volume of interest (5.39 ± 1.70 [SD] vs 8.50 ± 1.14, P < .005, two-tailed paired Student's t-test). Decreased N-acetyl-aspartate in the ipsilateral volume of interest was observed in all patients studied. No significant differences were found in the concentrations of creatine/phosphocreatine or choline compounds between the ipsilateral and contralateral volumes of interest. These findings give possible new insight into the pathophysiology of this disease and suggest that quantitative proton magnetic resonance spectroscopy may be useful for the early characterization and monitoring of neuronal dysfunction or loss in infants and children with Sturge-Weber syndrome. (J Child Neurol 1998; 13:332-335).

Journal of Child Neurology, Vol. 13, No. 7, 332-335 (1998)
DOI: 10.1177/088307389801300705


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