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Positron Emission Tomography Using [18F] Fluorodeoxyglucose and [ 11C] L-Methionine to Metabolically Characterize Dysembryoplastic Neuroepithelial Tumors

Division of Neurology, Department of Pediatrics, Maricopa Medical Center, Phoenix, AZ, Department of Child Neurology, University of Arizona, Tucson, AZ

Michael A. Lawson, MD

Division of Positron Emission Tomography Center, Phoenix Children's Hospital/Good Samaritan Regional Medical Center, Phoenix, AZ

Joseph Spataro, MD

Division of Neuropathology

Daniel J. Bandy, MS

Division of Positron Emission Tomography Center, Phoenix Children's Hospital/Good Samaritan Regional Medical Center, Phoenix, AZ

Charles T. Bonstelle, MD

Division of Radiology

S. David Moss, MD

Division of Neurosurgery

Kim H. Manwaring, MD

Division of Neurosurgery

Eric M. Reiman, MD

Division of Positron Emission Tomography Center, Phoenix Children's Hospital/Good Samaritan Regional Medical Center, Phoenix, AZ, Department of Psychiatry, University of Arizona, Tucson, AZ

Dysembryoplastic neuroepithelial tumors are unique and benign congenital tumors occurring frequently in children and adolescents. Differentiation from other low-grade tumors is important for management. Five patients with confirmed dysembryoplastic neuroepithelial tumors were studied with positron emission tomography using glucose and protein metabolic uptake in an attempt to categorize these tumors metabolically. Functional brain mapping also was obtained to aid in operative management. Results of the study conclude that dysembryoplastic neuroepithelial tumors, although having similar neuroimgaing characteristics to other low-grade tumors, are distinguished by a unique metabolic profile. They are inactive tumors with no significant glucose or protein metabolic activity. The combination of preoperative positron emission tomographic metabolic studies with functional brain mapping allowed for prediction of tumor type, defined eloquent areas of cortical function, and improved approach and resection of the tumors with minimal risk of neurologic impairment. (J Child Neurol 1999;14:673-677).

Journal of Child Neurology, Vol. 14, No. 10, 673-677 (1999)
DOI: 10.1177/088307389901401009


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