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Neurodevelopmental Outcome in Children With Intrauterine Growth Retardation: A 3-Year Follow-Up

Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv University, Tel Aviv, Israel

Yael Leitner, MD

Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv University, Tel Aviv, Israel

Miriam Kutai, MD

Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv University, Tel Aviv, Israel

Edith Tal-Posener, MD

Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv University, Tel Aviv, Israel

Abraham Tomer, MD

Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv University, Tel Aviv, Israel

Deborah Lieberman, MEd

Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv University, Tel Aviv, Israel

Ariel Jaffa, MD

Department of Obstetrics and Gynecology Lis Maternity Hospital, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Ariel Many, MD

Department of Obstetrics and Gynecology Lis Maternity Hospital, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Shaul Harel, MD

Institute for Child Development and Pediatric Neurology Unit, Division of Pediatrics, Tel Aviv University, Tel Aviv, Israel

The study was designed to detect early clinical predictors of developmental outcome in children with intrauterine growth retardation. Eighty-five children with intrauterine growth retardation were followed up prospectively to 3 years of age, using biometric parameters, perinatal risk questionnaires, and neurodevelopmental evaluations. Forty-two children served as controls. A significant difference in neurodevelopmental score at 3 years of age was noted between the intrauterine growth retardation and control groups (P < .001). In the intrauterine growth retardation group, the clinical parameters that most significantly correlated with outcome were cephalization index (head circumference:birthweight ratio), neonatal risk score, and birthweight. The best predictor of 3-year outcome was the cephalization index (P < .01). The children with intrauterine growth retardation with neonatal complications had significantly lower IQ scores (P < .05) and a poorer neurodevelopmental outcome (P < .01) than those without complications. Children with intrauterine growth retardation are at higher risk for developmental disabilities than are controls, especially in the presence of neonatal complications and a high cephalization index. (J Child Neurol 1999;14:724-727).

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