This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Barnard, C. Articles by Wirrell, E. Search for Related Content PubMed PubMed Citation Articles by Barnard, C. Articles by Wirrell, E. Social Bookmarking                         What's this?

Does Status Epilepticus in Children Cause Developmental Deterioration and Exacerbation of Epilepsy?

Division of Neurology, Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada

Elaine Wirrell, MD, FRCPC

Division of Neurology, Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, wirrell{at}duke.usask.ca

The aims of this study were to determine predictors of abnormal outcome, neurodevelopmental deterioration, new-onset epilepsy, refractory epilepsy, and recurrent status epilepticus in children presenting with status epilepticus. For all children presenting to Royal University Hospital, Saskatoon, Saskatchewan, Canada, with status epilepticus between January 1987 and December 1996, demographic data, details of status epilepticus (etiology, duration, treatment, and investigations), developmental milestones, seizures prior to and following status epilepticus, recurrent status epilepticus, and neurologic examination findings at status epilepticus and at follow-up were collected by chart review, patient interview, and neurologic examination. Neurodevelopmental outcome was determined for all subjects except those who died during the initial hospitalization. Predictors of new-onset epilepsy, refractory epilepsy, and recurrent status epilepticus were determined for children followed for 3 months or more after status epilepticus. At follow-up, 79% were abnormal neurologically. Predictors included etiology (nonfebrile or nonidiopathic), perinatal difficulties, preceding developmental delay, abnormal initial neurologic examination; and abnormal neuroimaging. Thirty-four percent showed neurodevelopmental deterioration; predictors included etiology (nonidiopathic or nonfebrile), young age at status epilepticus (12 months or less), and abnormal neuroimaging. Thirty-six percent with no history of seizures preceding status epilepticus developed epilepsy and 25% developed refractory epilepsy. Fifty percent of children had recurrent status epilepticus. In conclusion, very few children presenting in status epilepticus were normal at follow-up. Sequelae were seen predominantly in those with a nonidiopathic, nonfebrile etiology, whereas those with idiopathic or febrile status epilepticus did well. (J Child Neurol 1999;14:787-794).

Journal of Child Neurology, Vol. 14, No. 12, 787-794 (1999)
DOI: 10.1177/088307389901401204


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C. Cheung and E. Wirrell Adolescents' Perception of Epilepsy Compared With Other Chronic Diseases: "Through a Teenager's Eyes" J Child Neurol, March 1, 2006; 21(3): 214 - 222. [Abstract] [PDF]

				N. Oner, T. Fikret Cermik, M. Alpay, C.{t. Turan, N. Alada, and S. Karasalihoglu 99mTc-HMPAO Single Photon Emission Computed Tomography (SPECT) in Both Asphyxiated and Epileptic Children With or Without Status Epilepticus J Child Neurol, July 1, 2005; 20(7): 560 - 565. [Abstract] [PDF]

				M. Sahin, C. C. Menache, G. L. Holmes, and J. J. Riviello Jr. Prolonged treatment for acute symptomatic refractory status epilepticus: Outcome in children Neurology, August 12, 2003; 61(3): 398 - 401. [Abstract] [Full Text] [PDF]

				W. G. Mitchell Status Epilepticus and Acute Serial Seizures in Children J Child Neurol, January 1, 2002; 17(1_suppl): S36 - S43. [Abstract] [PDF]

				M. Sahin and J. J. Riviello JR Prolonged Treatment of Refractory Status Epilepticus in a Child J Child Neurol, February 1, 2001; 16(2): 147 - 150. [Abstract] [PDF]