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Topical Review: Hypertensive Encephalopathy, Reversible Occipitoparietal Encephalopathy, or Reversible Posterior Leukoencephalopathy: Three Names for an Old Syndrome

Department of Neurology, North Shore University Hospital, New York University, Manhasset, NY, SGP3038Caol.com, Department of Pediatrics North Shore University Hospital, New York University, Manhasset, NY

Yitzchak Frank, MD

Department of Neurology, North Shore University Hospital, New York University, Manhasset, NY, Department of Pediatrics North Shore University Hospital, New York University, Manhasset, NY

Rebecca Chusid, BA

Department of Neurology, North Shore University Hospital, New York University, Manhasset, NY

Children with hypertension, seizures, lethargy, encephalopathy, headache, and occipital blindness are reviewed. After undergoing antihypertensive therapy, most children improve. Some patients have a similar syndrome associated with chemotherapy, transplantation, transfusion, or human immunodeficiency virus-1 (HIV-1) infection. These latter children can develop symptoms with only minimal or no discernible elevations in blood pressure and improve, in the case of cancer-associated encephalopathy, after discontinuing chemotherapy. The reported children with this distinctive clinical condition are compared to adults with reversible posterior leukoencephalopathy syndrome. Since both gray and white matter are involved, we had suggested previously that the name be changed to (reversible) occipitoparietal encephalopathy syndrome. However, reversible posterior leukoencephalopathy has been used in the adult population and probably should be employed in children for the sake of uniformity, since both children and adults have the same clinical presentation and presumably a similar pathophysiology for the encephalopathy syndrome. The diagnosis is confirmed by reversible posterior abnormalities seen on T₂-weighted brain magnetic resonance imaging, and by the presence of either headache, altered mental status, seizures, or visual disturbances. (J Child Neurol 1999;14:277-281).

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