This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Vossler, D. G. Articles by Tae Sung Ko, Search for Related Content PubMed PubMed Citation Articles by Vossler, D. G. Articles by Tae Sung Ko, Social Bookmarking                   What's this?

Treatment of Seizures in Subcortical Laminar Heterotopia With Corpus Callosotomy and Lamotrigine

Epilepsy Center, Swedish Medical Center Seattle, WA, dvossler{at}swedish.org

Jung Kyo Lee, MD, PhD

Department of Neurosurgery, University of Ulsan College of Medicine, Seoul, Korea

Tae Sung Ko, MD

Department of Pediatrics Asan Medical Center, University of ULsan College of Medicine, Seoul, Korea

Focal and generalized cortical dysgeneses are sometimes seen on the magnetic resonance images (MRI) of patients with epilepsy. Subcortical laminar heterotopia are bilateral collections of gray matter in the centrum semiovale that resemble a band or "double cortex" on MRI. We studied one male and two female patients with subcortical laminar heterotopia who had moderate to severe developmental delay, early-onset epilepsy, and medically refractory seizures. Atonic, atypical absence, tonic, myoclonic, complex partial, and generalized tonic-clonic seizures were recorded. Interictal and ictal electroencephalographic patterns were generalized and, less commonly, multifocal. Two years after corpus callosotomy, one patient was free of generalized tonic-clonic and atonic seizures, but the other patient who had undergone callosotomy had no significant reduction in seizure frequency. With lamotrigine treatment, the patient who had not had surgery had complete cessation of monthly episodes of status epilepticus and a dramatic reduction of generalized tonic-clonic seizures, and the other patient who received lamotrigine had a 50% reduction of her atonic seizures. In patients with subcortical laminar heterotopia, atonic and generalized tonic-clonic seizures can be substantially reduced or eliminated by corpus cal losotomy or treatment with lamotrigine. (J Child Neurol 1999;14:282-288).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. D. D'Agostino, A. Bernasconi, S. Das, A. Bastos, R. M. Valerio, A. Palmini, J. Costa da Costa, I. E. Scheffer, S. Berkovic, R. Guerrini, et al. Subcortical band heterotopia (SBH) in males: clinical, imaging and genetic findings in comparison with females Brain, November 1, 2002; 125(11): 2507 - 2522. [Abstract] [Full Text] [PDF]