This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Chabot, R. J. Articles by Serfontein, G. Search for Related Content PubMed PubMed Citation Articles by Chabot, R. J. Articles by Serfontein, G. Social Bookmarking                         What's this?

Behavioral and Electrophysiologic Predictors of Treatment Response to Stimulants in Children with Attention Disorders

Department of Psychiatry, Brain Research Laboratories, New York University School of Medicine New York, NY, bob{at}br14.med.nyu.edu

Anna A. Orgill, MD

Serfontein Clinic for Developmental Paediatrics and Learning Disorders Sydney, Australia

Geoff Crawford, MD

Serfontein Clinic for Developmental Paediatrics and Learning Disorders Sydney, Australia

Michael J. Harris, MD

Serfontein Clinic for Developmental Paediatrics and Learning Disorders Sydney, Australia

Gordon Serfontein, MD

Serfontein Clinic for Developmental Paediatrics and Learning Disorders Sydney, Australia

Behavioral and quantitative electroencephalography (EEG) techniques were used to evaluate treatment response to stimulant therapy in children with attention disorders. A sample of 130 children with attention disorders were evaluated with Conners and Diagnostic and Statistical Manual of Mental Disorders-III rating scales, and with neurometric quantitative EEG before and 6 to 14 months after treatment with stimulants. Significant quantitative EEG differences were found between the normal control population (N = 31) and the children with attention problems. Quantitative EEG abnormalities involved increased theta or alpha power, greatest in frontal regions, frontal theta/alpha hypercoherence, and posterior interhemispheric power asymmetry. Behavioral improvement after stimulant treatment was seen in 81.5% of the children with attention-deficit hyperactivity disorder and 44.7% of the children with attention-deficit disorder, with the degree of correspondence between behavioral and quantitative EEG changes at 78.5%. Pretreatment clinical and quantitative EEG features could predict treatment response with a sensitivity of 83.1% and a specificity of 88.2%. A combined behavioral and quantitative EEG approach can be useful for following and predicting treatment response to stimulants in children with attention disorders. (J Child Neurol 1999;14:343-351).

Journal of Child Neurology, Vol. 14, No. 6, 343-351 (1999)
DOI: 10.1177/088307389901400601


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				H. M. Conklin, S. Helton, J. Ashford, R. K. Mulhern, W. E. Reddick, R. Brown, M. Bonner, B. W. Jasper, S. Wu, X. Xiong, et al. Predicting Methylphenidate Response in Long-Term Survivors of Childhood Cancer: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial J. Pediatr. Psychol., May 22, 2009; (2009) jsp044v1. [Abstract] [Full Text] [PDF]

				K. L. Coburn, E. C. Lauterbach, N. N. Boutros, K. J. Black, D. B. Arciniegas, and C. E. Coffey The Value of Quantitative Electroencephalography in Clinical Psychiatry: A Report by the Committee on Research of the American Neuropsychiatric Association J Neuropsychiatry Clin Neurosci, November 1, 2006; 18(4): 460 - 500. [Abstract] [Full Text] [PDF]

				N. Boutros, L. Fraenkel, and A. Feingold A Four-Step Approach for Developing Diagnostic Tests in Psychiatry: EEG in ADHD as a Test Case J Neuropsychiatry Clin Neurosci, November 1, 2005; 17(4): 455 - 464. [Abstract] [Full Text] [PDF]

				K. K. S. Voeller Attention-Deficit Hyperactivity Disorder (ADHD) J Child Neurol, October 1, 2004; 19(10): 798 - 814. [Abstract] [PDF]

				C. Heywood and I. Beale EEG biofeedback vs. placebo treatment for Attention-Deficit/Hyperactivity Disorder: A pilot study J Atten Disord, September 1, 2003; 7(1): 43 - 55. [Abstract] [PDF]

				R. J. Chabot, F. di Michele, L. Prichep, and E. R. John The Clinical Role of Computerized EEG in the Evaluation and Treatment of Learning and Attention Disorders in Children and Adolescents J Neuropsychiatry Clin Neurosci, May 1, 2001; 13(2): 171 - 186. [Abstract] [Full Text] [PDF]