Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Glauser, T. A.
Right arrow Articles by Pippenger, C.E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Glauser, T. A.
Right arrow Articles by Pippenger, C.E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Racial Differences in Free Radical Scavenging Enzyme Activity in Children

Tracy A. Glauser, MD

Children's Comprehensive Epilepsy Program, Department of Neurology, Children's Hospital Medical Center Cincinnati, OH

Melanie Titanic-Schefft, REEGT

Children's Comprehensive Epilepsy Program, Department of Neurology, Children's Hospital Medical Center Cincinnati, OH

C.E. Pippenger, PhD

FRESA Biomedical Laboratories Redmond, WA

Oxygen-derived free radicals play an important role in multiple pediatric neurologic diseases. Five intracellular free radical scavenging enzymes and three trace elements provide a significant portion of the body's defenses against free radical-mediated injury. Although the effects of age, sex, and ethnicity on the body's antioxidant defenses have been described, no study has examined whether racial differences exist. This pilot study sought to determine the effect of racial differences on the activity of five free radical scavenging enzymes and the concentrations of three associated trace elements in normal, healthy American children. The erythrocyte and plasma activities of five major free radical scavenging enzymes (glutathione peroxidase, glutathione reductase, glutathione-S-transferase, catalase, and superoxide dismutase) and plasma concentrations of three associated trace elements (selenium, copper, and zinc) were determined for 83 healthy American children, aged 1 to 18 years. One- and two-way interactions of race, age, and sex with each dependent variable were analyzed. African-Americans had higher erythrocyte glutathione peroxidase activity, erythrocyte superoxide dismutase activity, and selenium and copper concentrations than Caucasians. Racial inequalities do exist in free radical scavenging enzyme activity and trace element concentration in healthy children. African-American children had higher activity in the two most important free radical scavenging enzymes used by the brain compared to age- and sex-matched Caucasian children. Future clinical research in free radical-mediated pediatric neurologic diseases needs to consider race along with age and sex in both study design and data analysis. (J Child Neurol 1999;14:382-387).

Journal of Child Neurology, Vol. 14, No. 6, 382-387 (1999)
DOI: 10.1177/088307389901400607
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
J. E. Locke, D. S. Warren, F. Dominici, A. M. Cameron, M. S. Leffell, D. A. McRann, J. K. Melancon, D. L. Segev, C. E. Simpkins, A. L. Singer, et al.
Donor Ethnicity Influences Outcomes following Deceased-Donor Kidney Transplantation in Black Recipients
J. Am. Soc. Nephrol., October 1, 2008; 19(10): 2011 - 2019.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J. C. W. Mak, S. P. Ho, W. C. Yu, K. L. Choo, C. M. Chu, W. W. Yew, W. K. Lam, M. Chan-Yeung, and on behalf of the Hong Kong Thoracic Society Chroni
Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD
Eur. Respir. J., October 1, 2007; 30(4): 684 - 690.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
T. M. Vogt, R. G. Ziegler, B. H. Patterson, and B. I. Graubard
Racial Differences in Serum Selenium Concentration: Analysis of US Population Data from the Third National Health and Nutrition Examination Survey
Am. J. Epidemiol., August 1, 2007; 166(3): 280 - 288.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
A. C. Muntau, M. Streiter, M. Kappler, W. Roschinger, I. Schmid, A. Rehnert, P. Schramel, and A. A. Roscher
Age-related Reference Values for Serum Selenium Concentrations in Infants and Children
Clin. Chem., March 1, 2002; 48(3): 555 - 560.
[Abstract] [Full Text] [PDF]