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Seizures in Chiari I Malformation: A Clinical and Electroencephalographic Study

Department of Neurology, OASI Institute for Research on Mental Retardation and Brain Aging Troina, melia{at}oasi.en.it

Roberto Biondi, MD

Department of Neurology, University of Catania

Vito Sofia, MD

Department of Neurology, University of Catania

Sebastiano A. Musumeci, MD

Department of Neurology, OASI Institute for Research on Mental Retardation and Brain Aging Troina

Raffaele Ferri, MD

Department of Neurology, OASI Institute for Research on Mental Retardation and Brain Aging Troina

Giuseppe Capovilla, MD

Children's Neuropsychiatric Unit "C. Poma" Hospital Mantova

Paolo Curatolo, MD

Pediatric Neurology, University of Rome Tor Vergata, Rome, Italy

Seven subjects with Chiari I malformations and seizures (four males, three females; age range 11 years, 7 months to 36 years; mean, 22.28 ± 7.58 years; median, 21) were identified in four different centers from among a group of 10 patients. Our aim was to analyze clinical and electroencephalographic characteristics of seizures in this etiologically homogeneous group of patients. Most of the seizures were of the complex partial type, and paroxysmal abnormalities were mainly localized over the frontal and temporal regions. The course of the epilepsy was rather benign, with complete control of seizures in four patients and an important reduction in frequency in the remaining three subjects. Other cortical alterations are not usually associated with the typical abnormalities of the posterior fossa in Chiari I malformation; thus, it is possible to hypothesize that cerebral microdysgenesis or, alternatively, a cerebellar dysfunction could underlie epileptogenesis in these patients. (J Child Neurol 1999;14:446-450).

Journal of Child Neurology, Vol. 14, No. 7, 446-450 (1999)
DOI: 10.1177/088307389901400707


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