This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Anderson, A. Articles by Smith, K. Search for Related Content PubMed PubMed Citation Articles by Anderson, A. Articles by Smith, K. Pubmed/NCBI databases Medline Plus Health Information Premature Babies Social Bookmarking                         What's this?

Modeling Analysis of Change in Neurologic Abnormalities in Children Born Prematurely: A Novel Approach

Department of Pediatrics, Pediatric Neurology, Cain Foundation Laboratories, aander{at}ligand.neusc.bcm.tmc.edu, Department of Neurology, Clinical Neurophysiology, Baylor College of Medicine Houston, TX

Paul Swank, PhD

Department of Educational Psychology, University of Houston Houston, TX

Susan Wildin, MD

Department of Pediatrics, Child Development, University of Texas Medical Branch Galveston, TX

Susan Landry, PhD

Department of Pediatrics, Developmental Pediatrics, University of Texas Health Science Center Houston, TX

Karen Smith, PhD

Department of Pediatrics, Child Development, University of Texas Medical Branch Galveston, TX

The purpose of this longitudinal study was to evaluate changes in neurologic abnormalities in 212 preterm and 128 full-term children. Preterm infants with severe medical complications were considered at high risk, while those with milder complications were considered at low risk for neurodevelopmental abnormality. The patterns of change in neurologic status for the high- and low-risk preterm and term groups across 6, 12, 24, 40, and 54 months of age were compared using growth modeling analysis. As expected, the term group showed minimal change, while the two preterm groups demonstrated complex, nonlinear patterns of change in neurologic abnormalities. While the results demonstrate improvement over time in both groups of preterm infants, 35% of the children in the high-risk group had neurologic scores in the borderline or abnormal range at 54 months. These findings demonstrate that neurologic deficits are still evident at preschool age in some preterm children and that these deficits are related to the severity of neonatal complications. (J Child Neurol 1999;14:502-508).

Journal of Child Neurology, Vol. 14, No. 8, 502-508 (1999)
DOI: 10.1177/088307389901400804


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. F. Samsom and L. de Groot Study of a Group of Extremely Preterm Infants (25--27 Weeks): How Do They Function at 1 Year of Age? J Child Neurol, November 1, 2001; 16(11): 832 - 837. [Abstract] [PDF]