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Neurotrophin-3 Levels in Cerebrospinal Fluid From Children With Bacterial Meningitis, Viral Meningitis, or Encephalitis

Department of Pediatric Infectious Disease, Fukuoka Children's Hospital and Medical Center for Infectious Diseases Fukuoka, Japan, YR100265{at}niftyserve.or.jp

Hidetoshi Takada, MD

Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Kyoko Urakami, MD

Department of Pediatric Infectious Disease, Fukuoka Children's Hospital and Medical Center for Infectious Diseases Fukuoka, Japan

Kenji Ihara, MD

Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Ryutaro Kira, MD

Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Aiko Suminoe, MD

Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Shouichi Ohga, MD

Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Tomonobu Aoki, MD

Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Toshiro Hara, MD

Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan

Neurotrophin-3 levels were measured in the cerebrospinal fluid of 35 patients with bacterial meningitis, viral meningitis, or encephalitis by two-site enzyme immunoassay. Elevated cerebrospinal fluid levels of neurotrophin-3 were demonstrated in 8 of 18 patients with bacterial meningitis. Follow-up examination of the eight patients at the convalescent stage showed diminished cerebrospinal fluid levels of neurotrophin-3. In contrast, none of the 17 patients with viral meningitis or encephalitis showed an elevation of neurotrophin-3 levels in cerebrospinal fluid. No relationships were observed between neurotrophin-3 levels and cerebrospinal fluid cell numbers, cerebrospinal fluid protein levels, serum C-reactive protein concentrations, or outcome in bacterial meningitis. Since neurotrophin-3 is involved in the survival of neurons and the modulation of the immune system, neurotrophin-3 could play a neuroprotective or immunomodulatory role in bacterial meningitis. (J Child Neurol 2000;15:19-21).

Journal of Child Neurology, Vol. 15, No. 1, 19-21 (2000)
DOI: 10.1177/088307380001500104


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