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Asperger's Syndrome, X-Linked Mental Retardation (MRX23), and Chronic Vocal Tic Disorder

Child Evaluation and Treatment Program Grand Forks, North Dakota

Larry Burd, PhD

Child Evaluation and Treatment Program Grand Forks, North Dakota, laburd{at}mail.med.und.nodak.edu

Jacob Kerbeshian, MD

Child Evaluation and Treatment Program Grand Forks, North Dakota

Amy Stenehjem, MS

Child Evaluation and Treatment Program Grand Forks, North Dakota

Lisa A. Franceschini, MS

Child Evaluation and Treatment Program Grand Forks, North Dakota

Pervasive developmental disorders are severe disorders of development with no consistent neurobiologic etiology and most often an idiopathic etiology. We report a 12-year-old male who met criteria for a pervasive developmental disorder (Asperger's syndrome) and a chronic tic disorder. The child also has an X-linked cognitive impairment (MRX23). The presence of tic symptomatology, pervasive developmental disorder, and fragile X syndrome has previously been reported. Since no singular etiology for Asperger's syndrome has been found, the possibility of other cases of Asperger's syndrome occurring with concurrent abnormalities on the X chromosome should be considered by clinicians, especially if tic symptomatology is present. (J Child Neurol 2000; 15:699-702).

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