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Continuous Neostigmine Infusion in Post-Thymectomy Juvenile Myasthenic Crisis

Pediatric Intensive Care Unit, University of Athens, Athens, Greece, briassg{at}otenet.gr

Tassos Hatzis, MD, PhD

Pediatric Intensive Care Unit, University of Athens, Athens, Greece, briassg{at}otenet.gr

Theodota Liakopoulou, MD, PhD

First Department of Pediatrics,University of Athens Athens, Greece

Sotiris Youroukos, MD, PhD

First Department of Pediatrics University of Athens Athens, Greece

A 10-year-old boy with myasthenia gravis had severe post-thymectomy myasthenic crisis necessitating reintroduction of mechanical ventilation on the 5th day after thymectomy. He did not respond to therapy with oral pyridostigmine, corticosteroids, or high-dose intravenous immunoglobulin. Finally, in addition to the usual supportive care, he was treated successfully with continuous intravenous infusion of neostigmine. Continuous infusion of neostigmine was used for the first time in post-thymectomy myasthenic crisis in a child to the best of our knowledge. (J Child Neurol 2000; 15:747-749).

Journal of Child Neurology, Vol. 15, No. 11, 747-749 (2000)
DOI: 10.1177/088307380001501106


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