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Asymmetric Crying Facies and Associated Congenital Anomalies: Prospective Study and Review of the Literature

Pediatric Neurology Division, Sackler Faculty of Medcine, Tel-Aviv Universty

Eli Heyman, MD

Neonatology Department Assaf Harofeh Medical Center, Zerifm, Sackler Faculty of Medicine, Tel-Aviv University

Adaya Barkay, MD

Mother, Child and Adolescent Health Department, Ministry of Health Jerusalem, Israel

Michael Goldberg, MD

Neonatology Department Assaf Harofeh Medical Center, Zerifm, Sackler Faculty of Medicine, Tel-Aviv University

Congenital asymmetric crying facies, a minor congenital anomaly due to absence or hypoplasia of the depressor anguli oris muscle on one side of the mouth, is associated at times with major congenital anomalies, most commonly in the cardiovascular system. In a prospective study of 5532 infants born at the Assaf Harofeh Medical Center, Israel, during 12 months (January to December 1998), 17 infants (an incidence of 0.31%) had asymmetric crying facies. One of the affected infants had ventricular septal defect and another infant had VATER (vertebral defects, imperforate anus, tracheoesophageal fistula, and radial and renal dysplasia) syndrome. No noxious obstetric perinatal factors could be identified. Family history was unremarkable in all cases. Diagnostic work-up performed in all of the affected infants failed to reveal an additional congenital malformation. Asymmetric crying facies is a minor isolated finding in most of the cases; however, a thorough search for other congenital malformations, especially of the cardiovascular system, should be performed. (J Child Neurol 2000;15:808-810).

Journal of Child Neurology, Vol. 15, No. 12, 808-810 (2000)
DOI: 10.1177/088307380001501208


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