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Journal of Child Neurology
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Hypotension Following the Initiation of Tizanidine in a Patient Treated With an Angiotensin Converting Enzyme Inhibitor for Chronic Hypertension

Tiffanie R. Johnson, MD

Departments of Child Health and Anesthesiology Division of Pediatric Critical Care/ Pediatric Anesthesiology The University of Missouri Columbia, Missouri

Joseph D. Tobias, MD

Departments of Child Health and Anesthesiology Division of Pediatric Critical Care/ Pediatric Anesthesiology The University of Missouri Columbia, Missouri, Tobiasj{at}health.missouri.edu

Centrally acting alpha-2 adrenergic agonists are one of several pharmacologic agents used in the treatment of spasticity related to disorders of the central nervous system. In addition to their effects on spasticity, certain adverse cardiorespiratory effects have been reported. Adults chronically treated with angiotensin converting enzyme inhibitors may have a limited ability to respond to hypotension when the sympathetic response is simultaneously blocked. The authors present a 10-year-old boy chronically treated with lisinopril, an angiotensin converting enzyme inhibitor, to control hypertension who developed hypotension following the addition of tizanidine, an alpha-2 agonist, for the treatment of spasticity. The possible interaction of tizanidine and other antihypertensive agents should be kept in mind when prescribing therapy to treat either hypertension or spasticity in such patients. (J Child Neurol 2000;15:818-819).

Journal of Child Neurology, Vol. 15, No. 12, 818-819 (2000)
DOI: 10.1177/088307380001501211
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 The Annals of PharmacotherapyHome page
C.-D. Kao, J.-B. Chang, J.-T. Chen, Z.-A. Wu, D.-E Shan, and K.-K. Liao
Hypotension Due to Interaction Between Lisinopril and Tizanidine
Ann. Pharmacother., November 1, 2004; 38(11): 1840 - 1843.
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