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Midline Developmental Anomalies With Lipomas in the Corpus Callosum Region

Department of Pediatric Neurology, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany, mkieslich{at}zki.uni-frankfurt.de

Silke Ehlers, MD

Department of Pediatric Neurology, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany

Matthias Bollinger, MD

Department of Pediatric Neurology, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany

Gert Jacobi, MD

Department of Pediatric Neurology, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany

Three children with complete or partial callosal aplasia and intracranial lipoma in the corpus callosum region were investigated. Two lipomas were tubulonodular; one replaced the entire corpus callosum structure. Accompanying anomalies affected the cingulate gyrus, septum pellucidum, and choroid plexus. In one case, diagnosis was made in utero in the 25th gestational week by ultrasonography; in the second case it was made on the first day of life, also by screening ultrasonography. Two children had mild spastic distal diparesis; one complained of chronic headache. Electroencephalography showed no abnormalities; epilepsy anamnesis was negative. Somatosensory and visual evoked potentials showed prolonged conduction in two cases. Surgery was not indicated. Because of the risk of developing epileptic seizures, regular electroencephalographic follow-up investigations are essential. (J Child Neurol 2000; 15:85-89).

Journal of Child Neurology, Vol. 15, No. 2, 85-89 (2000)
DOI: 10.1177/088307380001500205


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