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Developmental Changes in Cerebrospinal Fluid Concentrations of Monoamine-Related Substances Revealed With a Coulochem Electrode Array System

Department of Pediatrics

Hiroko Matsushita, MD

Department of Pediatrics

Hisahiro Sakai, MD

Department of Pediatrics

Hisashi Kawano, MD

Department of Pediatrics

Kanji Yoshimoto

Department of Legal Medicine

Tadashi Sawada, MD

Department of Pediatrics Kyoto Prefectural University of Medicine Kyoto, Japan

The relationship between age and cerebrospinal fluid concentrations of monoamine-related substances, including kynurenine, were investigated using a Coulochem electrode array system, to clarify developmental changes in monoamine-related substances in the human central nervous system. In neurologically normal children, significant inverse correlations with age were observed for the cerebrospinal fluid concentrations of 5-hydroxytryptophan, 5-hydroxyindole-acetic acid, kynurenine, homovanillic acid, 3-methoxy-4- hydroxyphenyl glycol, and 3-O-methyl-dopamine. The concentrations of their precursors, tryptophan and tyrosine, were not related to age. This is the first comprehensive study revealing developmental changes in monoamine-related substances including their precursors and metabolites. (J Child Neurol 2000;15:267-270).

Journal of Child Neurology, Vol. 15, No. 4, 267-270 (2000)
DOI: 10.1177/088307380001500415


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