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Pleomorphic Xanthoastrocytoma Derived From Glioneuronal Malformation in a Child With Intractable Epilepsy

Department of Pediatrics

Nicolas von der Weid, MD

Department of Pediatrics

Luca Remonda, MD

Department of Neuroradiology

Luigi Mariani, MD

Department of Neurosurgery

Joachim Weis, MD

Institute of Pathology University of Berne Berne, Switzerland

Malformative lesions as well as neoplasms can cause intractable epilepsy in childhood. Even though the neoplastic nature of a lesion is evident in most cases, the distinction can be difficult in some patients. We present the case of a child with intractable epilepsy caused primarily by a glioneuronal malformation. Years after the first surgical intervention, a pleomorphic xanthoastrocytoma evolved from remnants of this lesion. This case suggests that glioneuronal malformations might be precursor lesions of pleomorphic xanthoastrocytomas. (J Child Neurol 2000;15: 270-272).

Journal of Child Neurology, Vol. 15, No. 4, 270-272 (2000)
DOI: 10.1177/088307380001500416


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