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Diffusion and Perfusion Magnetic Resonance Imaging in Childhood Stroke

Radiology and Physics Unit, University College London Medical School, dgadian{at}ich.ucl.ac.uk

Fernando Calamante, BSc

Radiology and Physics Unit, University College London Medical School

Fenella J. Kirkham, MB, BChir

Neurosciences Unit Institute of Child Health, University College London Medical School

Michael Bynevelt, BHB, MBChB, FRANZCR

Department of Radiology Great Ormond Street Hospital for Children, London, UK

Cheryl L. Johnson, DCR

Department of Radiology Great Ormond Street Hospital for Children, London, UK

David A. Porter, PhD

Radiology and Physics Unit, University College London Medical School

Wui K. Chong, MD, FRCR

Department of Radiology Great Ormond Street Hospital for Children, London, UK

Mara Prengler, MD

Neurosciences Unit Institute of Child Health, University College London Medical School

Alan Connelly, PhD

Radiology and Physics Unit, University College London Medical School

Two magnetic resonance imaging techniques, diffusion and perfusion imaging, are being used increasingly for evaluation of pathophysiology of stroke. This article introduces these techniques and reports some initial studies using these approaches, together with conventional T₂-weighted magnetic resonance imaging, for investigation of childhood stroke. It is shown that the combination of T₂-weighted and diffusion images can provide information about the timing of stroke events in childhood, and perfusion imaging can detect abnormalities not visible by other magnetic resonance imaging techniques. These magnetic resonance methods therefore should play an important role in investigation of children with stroke and could be of particular value in studies of at-risk populations of children such as those with sickle cell disease. (J Child Neurol 2000;15:279-283).

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