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Journal of Child Neurology
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Stroke in Children: Genetic and Metabolic Issues

Steven G. Pavlakis, MD

Department of Neurology and Pediatrics, Beth Israel Medical Center and Albert Einstein College of Medicine New York, SGP3038{at}aol.com

Peter B. Kingsley, PhD

Departments of Radiology, North Shore University Hospital, Manhasset, New York University Medical College New York, NY

Martin G. Bialer, MD, PhD

Department of Pediatrics North Shore University Hospital, Manhasset, New York University Medical College New York, NY

The study of genetic and metabolic etiologies of pediatric stroke, both vascular and metabolic, allows an understanding of the causes of acute focal neurologic deficits in childhood. Here, the mendelian and mitochondrial genetic causes of pediatric stroke syndromes are reviewed. This approach elucidates the etiology of childhood stroke and illustrates many of the genetic risk factors that are found in adult-onset cerebrovascular disease. Therefore, the study of childhood stroke serves as a model to elucidate the potential risk factors for all stroke. Ultimately this will serve to develop a more rational preventive and therapeutic approach for all cerebrovascular disease. (J Child Neurol 2000;15:308-315).

Journal of Child Neurology, Vol. 15, No. 5, 308-315 (2000)
DOI: 10.1177/088307380001500507
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