Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for FREE ACCESS to this landmark database

Click here to sign up for SAGE Journal Email Alerts today!
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Rasmussen, M.
Right arrow Articles by Skjeldal, O. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rasmussen, M.
Right arrow Articles by Skjeldal, O. H.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*VALPROIC ACID
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Evidence That Alpers-Huttenlocher Syndrome Could Be a Mitochondrial Disease

Magnhild Rasmussen, MD, PhD

Department of Pediatrics, National Hospital, Oslo, Norway

Truls Sanengen, MD, PhD

Department of Pediatrics, National Hospital, Oslo, Norway

Kari Skullerud, MD, PhD

Department of Pathology, National Hospital, Oslo, Norway

Eli Anne Kvittingen, MD, PhD

Institute of Clinical Biochemistry, National Hospital, Oslo, Norway

Ola H. Skjeldal, MD, PhD

Department of Pediatrics, National Hospital, Oslo, Norway

We report an 11-year-old boy with a slight developmental delay and epilepsy. After he was placed on valproate, he developed hepatic failure and increasing neurologic symptoms, including epilepsia partialis continua, and died. Autopsy findings in liver and cerebrum were consistent with progressive neuronal degeneration of childhood with liver disease, also called Alpers-Huttenlocher syndrome. Ragged red fibers and cytochrome c oxidase negative fibers were present in muscle. These results suggest that Alpers-Huttenlocher syndrome, at least in some patients, is a mitochondrial disease. (J Child Neurol 2000; 15:473-477).

Journal of Child Neurology, Vol. 15, No. 7, 473-477 (2000)
DOI: 10.1177/088307380001500709
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 BrainHome page
C. G. Bien, T. Granata, C. Antozzi, J. H. Cross, O. Dulac, M. Kurthen, H. Lassmann, R. Mantegazza, J.-G. Villemure, R. Spreafico, et al.
Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: A European consensus statement
Brain, March 1, 2005; 128(3): 454 - 471.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J te Water Naude, C M Verity, R G Will, G Devereux, and L Stellitano
Is variant Creutzfeldt-Jakob disease in young children misdiagnosed as Alpers' syndrome? An analysis of a national surveillance study
J. Neurol. Neurosurg. Psychiatry, June 1, 2004; 75(6): 910 - 913.
[Abstract] [Full Text] [PDF]