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Journal of Child Neurology
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Unilateral Periventricular Nodular Heterotopia Associated With Diffuse Areas of Cerebral Functional Abnormalities

Renato Borgatti, MD

Department of Child Neuropsychiatry Bugenio Medea Scientific Insitate, borgatti{at}bp.lnf.it

Claudio Zucca, MD

Clinical Neurophysiology Unit Eugenio Medea Scientific Institute

Paolo Piccinelli, MD

Child Neuropsychiatry Unit

H. Fondazione Macchi

University of Varese Varese

Lucia Radice, MD

Clinical Neurophysiology Unit Bugenio Medea Scientific Institute Bosisio Parini (Lecco)

Annalisa Tofani, MD

Department of Child Neuropsychiatry Eugenio Medea Scientific Institute Bosisio Parini (Lecco)

Riccardo Benti, MD

Nuclear Medicine Service Ospedale Maggiore Scientific Institute

Fabio Triulzi, MD

Department of Neuroradiology H.S. Raffaele Scientific Institute Milan, Italy

A 17-year-old boy with polymorphic simple and complex partial seizures is described. Magnetic resonance imaging revealed a unilateral periventricular nodular heterotopia near the occipital ventricular right horn. Interictal and ictal electroencephalographic recordings showed bilateral specific epileptiform anomalies in the occipital region and asynchronous slow waves in frontal areas. Single photon emission computed tomography documented a reduction in regional cerebral blood flow in an area of the left occipital cortex and a symmetric increase in tracer uptake in the frontal lobes. The neuropsychologic assessment revealed a dysfunction of the frontal associative areas. Data collected led the authors to suspect a more diffuse cortical dysfunction than the nodular heterotopia revealed on magnetic resonance imaging. (J Child Neurol 2000;15: 622-626).

Journal of Child Neurology, Vol. 15, No. 9, 622-626 (2000)
DOI: 10.1177/088307380001500910
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